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Methods: With the use of a systematic literature review of PubMed, Embase, Web of Science, and the Cochrane Library databases through July 2021, randomized controlled trials that compared the free up-titration or FRC with remaining on GLP-1RA in T2DM patients uncontrolled with GLP-1RA were included
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In particular, GLP‐1 receptor is highly expressed in beta cells but at much lower levels in neurons and other tissues (Richards et al., 2014)
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