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Targeted inhibition of DPP-4 reduces angiotensin (Ang) II elevation, whereas inhibitors of the angiotensin I-converting enzyme (ACE) or Ang II type 1 receptor (AT1R) blockers downregulate DPP-4 activity in experimental models of cardiometabolic diseases, evidencing a bidirectional relationship between DPP-4 and Ang II [65]
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