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The hypoglycemia risk most articles underestimate The published tirzepatide prescribing information focuses on hypoglycemia risk in patients taking concurrent insulin or sulfonylureas, but a 2024 post-marketing surveillance study found that 12% of tirzepatide overdose patients without diabetes experienced symptomatic hypoglycemia (blood glucose below 70 mg/dL with symptoms) even without concurrent medications (Lingvay et al., Journal of Clinical Endocrinology & Metabolism , 2024)

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However, standard commercial protocols often force a choice between the two, locking individuals into a single pathway that may not fully address their unique medical needs