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Several paracrine mechanisms within the pancreatic islet govern the secretion of insulin and glucagon
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Interestingly, the question of splitting tirzepatide doses comes up just as frequently, and the pharmacokinetic rationale is similar
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![Structure of semaglutide (subcutaneous formulation) [23]](https://www.researchgate.net/publication/395448714/figure/fig3/AS:11431281635754999@1757967331326/Structure-of-semaglutide-subcutaneous-formulation-23_Q320.jpg)
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